Protein deneddylation

Across TCGA cell cohorts, RNA activity of the Protein deneddylation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTR2, BBS7, and LNPK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein deneddylation activity versus ACTR2 in LIVER (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ACTR2 →	+1.082	+2.660	.006	<.001	3	5
BREAST	BBS7 →	+0.777	+1.375	.003	.005	3	5
SKIN	LNPK →	+0.642	+1.249	.001	<.001	3	5
STOMACH	SAP30 →	+1.250	+1.876	<.001	<.001	3	5
STOMACH	CHAF1A →	+0.982	+1.487	.008	.001	3	5
BLOOD_Myeloma	PPP1R12B →	+0.884	+0.442	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000338 vs ACTR2 — LIVER

Explore this scatter interactively →