Q-omics provides the consensus-scored ZSWIM1 profile across patient tissues and cancer cell-line models. ZSWIM1 expression is associated with patient survival in 29 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, ZSWIM1 is differentially expressed in 16, with the highest sampling consensus in HNSC. Additionally, ZSWIM1 RNA expression shows 19,695 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight UVM, HNSC, and ACC as cancer lineages where ZSWIM1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ZSWIM1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ZSWIM1 survival associations across molecular data types. ZSWIM1 RNA expression shows survival associations in the most cancer types (29), followed by mutation status (3) and mass-spec protein abundance (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ZSWIM1 RNA expression–survival associations across cancer types. High ZSWIM1 expression shows unfavorable associations in UVM, LIHC, KIRC, SKCM and MESO, but favorable associations in READ. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for ZSWIM1 RNA expression.
This table summarizes ZSWIM1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 16, while mass-spec protein shows differences in 2. The strongest signals are observed in HNSC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for ZSWIM1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ZSWIM1 shows higher tumor expression in HNSC, COAD, LIHC, STAD, LUSC and LUAD. The HNSC box plot shows higher ZSWIM1 RNA expression in tumor versus normal tissue (log2 FC = +0.917, t-test p < 0.001).
This table shows molecular features associated with ZSWIM1 in patient tissues and cancer cell lines. In patient samples, ZSWIM1 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, ZSWIM1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUAD, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and UPPER_AERODIGESTIVE_TRACT.
