ZSWIM1

Across TCGA patient cohorts, ZSWIM1 mutation is significantly associated with the RNA expression of many other genes, with 1,194 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSWIM1-associated genes across cancer lineages are CCL4, CCL3, and ADAM33. Each is linked with ZSWIM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZSWIM1-to-partner and partner-to-ZSWIM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL4 grouped by ZSWIM1-low versus ZSWIM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSWIM1→partner) and Y-score (partner→ZSWIM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCL4 →	+1.211	+2.423	<.001	.001	3	2
UCEC	CCL3 →	+0.949	+2.447	<.001	.001	3	2
UCEC	ADAM33 →	-0.907	-3.406	.005	.005	3	2
UCEC	SKA1 →	+0.661	+2.609	.002	.005	3	2
COAD	GFI1 →	+0.750	+3.479	.007	.002	3	2
UCEC	CTLA4 →	+0.834	+2.595	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,194 associations by consensus.

CCL4 by ZSWIM1 expression — UCEC

Explore this box plot interactively →