ZSWIM1

Across TCGA patient cohorts, ZSWIM1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSWIM1-associated genes across cancer lineages are FASN, N-Cadherin, and Stathmin. Each is linked with ZSWIM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZSWIM1-to-partner and partner-to-ZSWIM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by ZSWIM1-low versus ZSWIM1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSWIM1→partner) and Y-score (partner→ZSWIM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FASN →	+0.402	+2.330	.022	.020	3	1
COAD	N-Cadherin →	-0.154	-3.000	.045	.035	3	1
COAD	Stathmin →	+0.161	+2.330	.019	.020	3	1
COAD	Bcl-xL →	-0.268	-2.296	.012	.035	3	1
COAD	Cyclin-B1 →	+0.532	+3.169	.030	.018	3	1
UCEC	eIF4E →	+0.192	+3.321	.036	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

FASN by ZSWIM1 expression — COAD

Explore this box plot interactively →