ZNF593

Across TCGA patient cohorts, ZNF593 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF593-associated genes across cancer lineages are H3P46, IGKV2-40, and RNA5SP534. Each is linked with ZNF593 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF593-to-partner and partner-to-ZNF593 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H3P46 grouped by ZNF593-low versus ZNF593-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF593→partner) and Y-score (partner→ZNF593) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	H3P46 →	+0.164	+4.555	<.001	.005	3	1
UCEC	IGKV2-40 →	+0.482	+3.386	<.001	.008	3	1
UCEC	RNA5SP534 →	+0.605	+3.827	<.001	.003	3	1
UCEC	MIR6864 →	+1.040	+3.061	<.001	.008	3	1
UCEC	RN7SL650P →	+0.467	+3.944	.001	.002	3	1
UCEC	MIR6750 →	+0.822	+3.298	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

H3P46 by ZNF593 expression — UCEC

Explore this box plot interactively →