ZNF593

Across TCGA pan-cancer cohorts, ZNF593 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ZNF593’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ZNF593 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF593 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, BLCA, and STAD are the cancer types where ZNF593 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF593 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+1.429	<.001	12	view →
BLCA	All	All	+0.608	.004	10	view →
STAD	Female	All	+1.244	<.001	9	view →
KICH	Female	All	−1.150	<.001	8	view →
LUAD	Female	III,IV	+0.730	<.001	8	view →
HNSC	Male	All	+0.664	<.001	8	view →
LUSC	Male	II,III,IV	+0.720	<.001	7	view →
ESCA	All	II,III,IV	+1.009	.003	4	view →
CHOL	Male	All	+0.855	<.001	4	view →
LIHC	All	All	+0.372	.002	4	view →
READ	All	III,IV	+1.105	.008	3	view →
UCEC	All	All	+0.393	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ZNF593–COAD

Open the COAD breakdown →