ZNF593

Across TCGA pan-cancer cohorts, ZNF593 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated ZNF593 data layer compared with 7 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ZNF593 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF593 expression acts as an unfavorable survival marker, although some lineages such as COAD and ESCA show a favorable association.

KIRC, ACC, and LGG are the cancer types where ZNF593 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	II,III,IV	0.688	0.902	<.001	99	view →
ACC	OS	Median	All	0.464	0.768	.002	60	view →
LGG	DFS	Median	All	0.625	0.852	<.001	51	view →
HNSC	DFS	Tertile	All	0.669	0.801	.005	31	view →
UCS	DFS	Tertile	IV	0.237	0.938	.024	24	view →
LIHC	OS	Median	All	0.458	0.686	.009	19	view →
COAD	DFS	Median	III,IV	0.662	0.459	.003	19	view →
ESCA	DFS	Median	IV	0.634	0.205	.006	18	view →
PRAD	DFS	Tertile	All	0.745	0.906	<.001	18	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	14	view →
MESO	DFS	Median	All	0.477	0.305	.012	9	view →
READ	DFS	Median	III,IV	0.925	0.611	.017	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

ZNF593–KIRC (OS)

Open the KIRC breakdown →