ZNF586

Across TCGA patient cohorts, ZNF586 mutation is significantly associated with the RNA expression of many other genes, with 602 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF586-associated genes across cancer lineages are RNU6-319P, MIR3690, and RNU6ATAC36P. Each is linked with ZNF586 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF586-to-partner and partner-to-ZNF586 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-319P grouped by ZNF586-low versus ZNF586-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF586→partner) and Y-score (partner→ZNF586) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-319P →	+0.446	+4.080	.005	.004	3	2
UCEC	MIR3690 →	+0.369	+2.446	.001	.001	3	2
SKCM	RNU6ATAC36P →	+0.335	+5.199	.001	.003	3	2
CESC	MIR548AL →	+0.262	+4.757	<.001	.004	3	2
CESC	MIR3913-1 →	+0.291	+4.757	<.001	.004	3	2
CESC	TRAJ41 →	+0.504	+3.934	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 602 associations by consensus.

RNU6-319P by ZNF586 expression — BRCA

Explore this box plot interactively →