ZNF586

Across TCGA pan-cancer cohorts, ZNF586 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ZNF586’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZNF586 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF586 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and BRCA are the cancer types where ZNF586 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF586 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.496	<.001	9	view →
KICH	All	II,III,IV	−0.908	<.001	7	view →
BRCA	All	II,III,IV	+0.335	.001	6	view →
CHOL	Male	All	+1.676	<.001	5	view →
LIHC	All	All	+0.279	.003	5	view →
LUAD	Male	III,IV	−0.538	.006	4	view →
KIRP	Male	All	−0.461	.006	3	view →
KIRC	All	III,IV	−0.204	.033	2	view →
BLCA	Female	III,IV	+0.392	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ZNF586–THCA

Open the THCA breakdown →