ZNF483

Across TCGA cell cohorts, ZNF483 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF483-associated genes across cancer lineages are MFRP, PRSS54, and OR8D4. Each is linked with ZNF483 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF483-to-partner and partner-to-ZNF483 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MFRP grouped by ZNF483-low versus ZNF483-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF483→partner) and Y-score (partner→ZNF483) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MFRP →	+0.018	+4.684	<.001	.002	3	2
BLOOD_Leukemia	PRSS54 →	+0.036	+5.539	<.001	.003	3	1
BLOOD_Leukemia	OR8D4 →	+0.006	+5.539	<.001	.003	3	1
BLOOD_Leukemia	KRTAP10-8 →	+0.039	+5.969	<.001	.001	3	1
BLOOD_Leukemia	PRAMEF9 →	+0.006	+5.969	<.001	.001	3	1
BLOOD_Leukemia	KRTAP10-9 →	+0.013	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

MFRP by ZNF483 expression — SKIN

Explore this box plot interactively →