ZNF483

Across TCGA pan-cancer cohorts, ZNF483 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ZNF483’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZNF483 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF483 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and LUSC are the cancer types where ZNF483 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF483 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−0.348	<.001	11	view →
THCA	Male	All	−0.798	<.001	8	view →
LUSC	Male	All	−0.423	<.001	8	view →
UCEC	All	All	−0.997	<.001	6	view →
BRCA	Female	All	−0.657	<.001	6	view →
READ	All	All	−0.426	.008	4	view →
BLCA	All	All	−0.348	.023	4	view →
KICH	All	All	−0.414	.002	3	view →
LUAD	Female	II,III,IV	−0.357	<.001	3	view →
KIRP	All	All	−0.321	<.001	3	view →
COAD	All	II,III,IV	−0.112	.002	3	view →
STAD	All	All	−0.522	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ZNF483–KIRC

Open the KIRC breakdown →