ZNF345

Across TCGA cell cohorts, ZNF345 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF345-associated genes across cancer lineages are GDF3, OR4Q2, and OR10V1. Each is linked with ZNF345 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF345-to-partner and partner-to-ZNF345 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GDF3 grouped by ZNF345-low versus ZNF345-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF345→partner) and Y-score (partner→ZNF345) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GDF3 →	+0.010	+4.643	<.001	.004	3	1
BLOOD_Lymphoma	OR4Q2 →	+0.013	+6.247	<.001	<.001	3	1
BLOOD_Leukemia	OR10V1 →	+0.020	+4.247	<.001	.004	3	1
BLOOD_Leukemia	UBE2QL1 →	+0.150	+3.007	.006	.007	3	1
LARGE_INTESTINE	SH3GL2 →	+1.104	+3.474	.003	.003	3	1
LARGE_INTESTINE	TSFM →	+0.575	+3.192	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

GDF3 by ZNF345 expression — LUNG_SCLC

Explore this box plot interactively →