ZNF345

Across TCGA pan-cancer cohorts, ZNF345 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZNF345’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZNF345 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF345 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, LIHC, and UCEC are the cancer types where ZNF345 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF345 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.465	<.001	9	view →
LIHC	Female	II,III,IV	+0.580	<.001	7	view →
UCEC	All	All	−0.470	<.001	6	view →
BRCA	Female	All	−0.455	<.001	6	view →
HNSC	All	II,III,IV	−0.298	.004	6	view →
CHOL	Male	All	+1.356	<.001	5	view →
STAD	Male	All	−0.430	.014	4	view →
LUAD	Female	III,IV	−0.490	.006	3	view →
ESCA	Female	All	−1.046	.013	1	view →
KICH	All	All	−0.251	.048	1	view →
KIRC	All	All	+0.128	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ZNF345–THCA

Open the THCA breakdown →