ZNF345

Across TCGA pan-cancer cohorts, ZNF345 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ZNF345 data layer compared with 10 for mutation status.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher ZNF345 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF345 expression acts as an unfavorable survival marker, although some lineages such as UCS and HNSC show a favorable association.

UCS, HNSC, and BRCA are the cancer types where ZNF345 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	III,IV	0.545	0.176	<.001	76	view →
HNSC	DFS	Median	IV	0.723	0.560	.001	72	view →
BRCA	OS	Tertile	All	0.954	0.880	<.001	71	view →
LUAD	DFS	Tertile	All	0.841	0.655	<.001	57	view →
LGG	DFS	Median	All	0.638	0.838	<.001	54	view →
BLCA	OS	Median	All	0.534	0.349	<.001	44	view →
READ	OS	Quartile	II,III,IV	1.000	0.217	.002	30	view →
THYM	DFS	Median	II,III,IV	0.896	0.486	.005	25	view →
ACC	DFS	Tertile	All	0.431	0.776	.010	22	view →
OV	OS	Tertile	IV	0.616	0.344	.007	16	view →
LIHC	OS	Quartile	All	0.752	0.875	.009	16	view →
MESO	DFS	Quartile	IV	0.147	0.735	.017	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ZNF345–UCS (DFS)

Open the UCS breakdown →