ZNF226

Across TCGA patient cohorts, ZNF226 mutation is significantly associated with the RNA expression of many other genes, with 2,068 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF226-associated genes across cancer lineages are SOD1P1, PMM2P1, and VPS18. Each is linked with ZNF226 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF226-to-partner and partner-to-ZNF226 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SOD1P1 grouped by ZNF226-low versus ZNF226-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF226→partner) and Y-score (partner→ZNF226) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SOD1P1 →	+0.214	+3.434	<.001	<.001	3	3
BLCA	PMM2P1 →	+0.067	+5.289	<.001	.003	3	3
UCEC	VPS18 →	+0.582	+2.754	<.001	<.001	3	3
UCEC	LINC02446 →	+0.768	+2.346	<.001	<.001	3	3
UCEC	CTLA4 →	+0.882	+2.421	<.001	<.001	3	3
CESC	GPC5-IT1 →	+0.043	+4.569	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,068 associations by consensus.

SOD1P1 by ZNF226 expression — LUAD

Explore this box plot interactively →