ZNF226

Across TCGA pan-cancer cohorts, ZNF226 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ZNF226 data layer compared with 5 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher ZNF226 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF226 expression acts as an unfavorable survival marker, although some lineages such as BLCA and BRCA show a favorable association.

BLCA, UVM, and LGG are the cancer types where ZNF226 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	All	0.682	0.545	<.001	52	view →
UVM	DFS	Quartile	III,IV	0.182	0.823	<.001	45	view →
LGG	DFS	Median	All	0.646	0.829	<.001	43	view →
BRCA	OS	Median	III,IV	0.945	0.858	.005	30	view →
ACC	DFS	Quartile	All	0.486	1.000	<.001	22	view →
PAAD	OS	Quartile	All	0.587	0.269	.001	19	view →
SCLC	OS	Tertile	All	0.548	1.000	.011	17	view →
PRAD	OS	Median	All	0.987	1.000	.013	16	view →
SKCM	DFS	Quartile	II,III,IV	0.612	0.859	.008	15	view →
KIRC	DFS	Median	II,III,IV	0.636	0.743	.017	15	view →
LIHC	OS	Quartile	All	0.665	0.843	.011	14	view →
UCEC	OS	Median	III,IV	0.891	0.759	.015	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ZNF226–BLCA (DFS)

Open the BLCA breakdown →