long intergenic non-protein coding RNA 2446Genealiases: []
Q-omics provides the consensus-scored LINC02446 profile across patient tissues and cancer cell-line models. LINC02446 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, LINC02446 is differentially expressed in 7, with the highest sampling consensus in KIRC. Additionally, LINC02446 RNA expression shows 12,160 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight UVM, KIRC, and LSCC as cancer lineages where LINC02446 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LINC02446 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LINC02446 survival associations across molecular data types. LINC02446 RNA expression shows survival associations in the most cancer types (23). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LINC02446 RNA expression–survival associations across cancer types. High LINC02446 expression shows unfavorable associations in UVM and LGG, but favorable associations in SKCM, CESC, BLCA and HNSC. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for LINC02446 RNA expression.
This table summarizes LINC02446 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for LINC02446. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LINC02446 shows lower tumor expression in PAAD, COAD, UCEC and LIHC and higher tumor expression in KIRC and BRCA. The KIRC box plot shows higher LINC02446 RNA expression in tumor versus normal tissue (log2 FC = +0.956, t-test p < 0.001).
This table shows molecular features associated with LINC02446 in patient tissues and cancer cell lines. In patient samples, LINC02446 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set.
