Q-omics provides the consensus-scored ZNF181 profile across patient tissues and cancer cell-line models. ZNF181 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, ZNF181 is differentially expressed in 10, with the highest sampling consensus in THCA. Additionally, ZNF181 RNA expression shows 21,206 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRC, THCA, and UVM as cancer lineages where ZNF181 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ZNF181 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ZNF181 survival associations across molecular data types. ZNF181 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ZNF181 RNA expression–survival associations across cancer types. High ZNF181 expression shows unfavorable associations in LGG, but favorable associations in KIRC, HNSC, UCS, READ and PAAD. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for ZNF181 RNA expression.
This table summarizes ZNF181 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for ZNF181. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ZNF181 shows lower tumor expression in THCA, UCEC, LUAD, KIRP and KICH and higher tumor expression in LIHC. The THCA box plot shows higher ZNF181 RNA expression in normal versus tumor tissue (log2 FC = −1.170, t-test p < 0.001).
This table shows molecular features associated with ZNF181 in patient tissues and cancer cell lines. In patient samples, ZNF181 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, ZNF181 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Leukemia, while CRISPR and shRNA rows add functional-dependency signals in SKIN and LARGE_INTESTINE.
