Across TCGA patient cohorts, ZNF181 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF181-associated genes across cancer lineages are JNK_pT183_Y185, MEK1, and EGFR. Each is linked with ZNF181 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF181-to-partner and partner-to-ZNF181 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF181→partner) and Y-score (partner→ZNF181) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.148	-2.459	.022	.019	3	2
UCEC	MEK1 →	+0.352	+2.115	.012	.017	3	2
UCEC	EGFR →	-0.196	-2.115	.001	.017	3	1
UCEC	FoxM1 →	+0.196	+2.584	.048	.001	3	1
UCEC	ACC_pS79 →	+0.298	+2.179	.024	.034	3	1
UCEC	INPP4B →	-0.275	-1.664	.026	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

ZNF181 survival (RNA) · tumor vs normal (RNA) · all ZNF181 data types