ZFP3

Across TCGA cell cohorts, ZFP3 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZFP3-associated genes across cancer lineages are OR52E4, TECRL, and ACTRT1. Each is linked with ZFP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFP3-to-partner and partner-to-ZFP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52E4 grouped by ZFP3-low versus ZFP3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFP3→partner) and Y-score (partner→ZFP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR52E4 →	+0.012	+5.201	.008	.006	3	2
LARGE_INTESTINE	TECRL →	+0.026	+4.977	<.001	.007	3	1
BLOOD_Leukemia	ACTRT1 →	+0.038	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TRIM42 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	NKX2-6 →	+0.639	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR3A1 →	+1.055	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

OR52E4 by ZFP3 expression — BLOOD_Leukemia

Explore this box plot interactively →