ZFP3

Across TCGA pan-cancer cohorts, ZFP3 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ZFP3 data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZFP3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ZFP3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

HNSC, KIRC, and PAAD are the cancer types where ZFP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.758	0.632	<.001	141	view →
KIRC	DFS	Median	All	0.708	0.551	<.001	109	view →
PAAD	DFS	Tertile	All	0.464	0.245	<.001	66	view →
CESC	OS	Median	IV	0.836	0.380	.008	56	view →
LUAD	OS	Tertile	All	0.775	0.610	<.001	50	view →
KIRP	DFS	Quartile	All	1.000	0.483	.001	48	view →
READ	OS	Quartile	II,III,IV	0.913	0.338	.001	43	view →
ACC	OS	Quartile	IV	0.961	0.414	.006	26	view →
MESO	DFS	Median	IV	0.176	0.481	.005	21	view →
BLCA	OS	Tertile	All	0.549	0.356	.018	19	view →
UCS	OS	Tertile	III,IV	0.660	0.335	.018	18	view →
LGG	OS	Quartile	All	0.724	0.844	.010	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ZFP3–HNSC (DFS)

Open the HNSC breakdown →