ZEB2

Across TCGA patient cohorts, ZEB2 mutation is significantly associated with the RNA expression of many other genes, with 5,665 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZEB2-associated genes across cancer lineages are RNU2-27P, CHAF1B, and GMEB1. Each is linked with ZEB2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZEB2-to-partner and partner-to-ZEB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU2-27P grouped by ZEB2-low versus ZEB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZEB2→partner) and Y-score (partner→ZEB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU2-27P →	+0.678	+2.868	<.001	<.001	3	5
UCEC	CHAF1B →	+0.583	+2.857	<.001	<.001	3	5
COAD	GMEB1 →	+0.277	+2.526	.004	.009	3	5
UCEC	SPATA5L1 →	+0.376	+1.470	<.001	<.001	3	5
LUAD	IGSF22 →	-0.239	-2.008	.003	.005	3	4
COAD	RCC1 →	+0.414	+2.625	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,665 associations by consensus.

RNU2-27P by ZEB2 expression — UCEC

Explore this box plot interactively →