ZDHHC24

Across TCGA patient cohorts, ZDHHC24 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZDHHC24-associated genes across cancer lineages are MTND2P30, OR8F1P, and RN7SL795P. Each is linked with ZDHHC24 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZDHHC24-to-partner and partner-to-ZDHHC24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND2P30 grouped by ZDHHC24-low versus ZDHHC24-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZDHHC24→partner) and Y-score (partner→ZDHHC24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MTND2P30 →	+0.131	+5.513	<.001	.004	3	2
SKCM	OR8F1P →	+0.050	+5.224	.006	.007	3	1
SKCM	RN7SL795P →	+0.174	+5.771	<.001	.003	3	1
COAD	RNU6-591P →	+0.373	+7.741	<.001	.009	3	1
COAD	FAM197Y1 →	+0.064	+7.741	<.001	.009	3	1
COAD	FAM41AY1 →	+0.054	+7.741	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

MTND2P30 by ZDHHC24 expression — SKCM

Explore this box plot interactively →