ZDHHC24

Across TCGA pan-cancer cohorts, ZDHHC24 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ZDHHC24 data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher ZDHHC24 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ZDHHC24 expression acts as an unfavorable survival marker, although some lineages such as STAD and UCEC show a favorable association.

STAD, UVM, and UCEC are the cancer types where ZDHHC24 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Tertile	III,IV	0.630	0.400	.001	64	view →
UVM	DFS	Tertile	All	0.416	0.721	.002	63	view →
UCEC	DFS	Tertile	All	0.764	0.527	.002	60	view →
KICH	DFS	Median	III,IV	0.357	0.942	.004	52	view →
SCLC	OS	Quartile	All	0.813	0.492	.004	35	view →
LGG	OS	Tertile	All	0.842	0.929	.002	23	view →
LIHC	OS	Tertile	All	0.714	0.848	.002	21	view →
ACC	DFS	Quartile	All	0.243	0.745	.001	20	view →
LUAD	DFS	Median	All	0.708	0.822	.014	16	view →
READ	OS	Tertile	III,IV	0.242	0.790	.003	15	view →
LUSC	DFS	Quartile	III,IV	0.405	0.935	.020	14	view →
BLCA	OS	Tertile	All	0.490	0.732	.015	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ZDHHC24–STAD (OS)

Open the STAD breakdown →