ZC3H12D

Across TCGA patient cohorts, ZC3H12D mutation is significantly associated with the RNA expression of many other genes, with 1,391 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3H12D-associated genes across cancer lineages are H3P17, RNU6-769P, and RN7SL248P. Each is linked with ZC3H12D in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC3H12D-to-partner and partner-to-ZC3H12D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H3P17 grouped by ZC3H12D-low versus ZC3H12D-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H12D→partner) and Y-score (partner→ZC3H12D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	H3P17 →	+0.071	+4.897	<.001	.002	3	2
LIHC	RNU6-769P →	+0.393	+6.479	<.001	.001	3	2
UCEC	RN7SL248P →	+0.066	+3.307	<.001	.003	3	2
UCEC	RN7SL237P →	+0.327	+2.955	<.001	<.001	3	2
UCEC	TRAJ28 →	+0.517	+1.939	<.001	.007	3	2
UCEC	NFYBP1 →	+0.148	+2.001	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,391 associations by consensus.

H3P17 by ZC3H12D expression — SKCM

Explore this box plot interactively →