ZC3H12D

Across TCGA pan-cancer cohorts, ZC3H12D RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZC3H12D’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZC3H12D RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZC3H12D is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KIRC, HNSC, and KICH are the cancer types where ZC3H12D tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZC3H12D RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.738	<.001	11	view →
HNSC	All	All	+0.248	.001	7	view →
KICH	All	II,III,IV	−0.422	<.001	6	view →
STAD	Female	All	+1.550	<.001	5	view →
KIRP	Female	II,III,IV	−0.647	<.001	5	view →
COAD	Female	All	−0.548	<.001	5	view →
LIHC	All	All	+0.174	.004	5	view →
BRCA	Female	All	+0.267	<.001	4	view →
THCA	All	III,IV	+0.410	.006	3	view →
ESCA	Female	All	+1.750	.013	2	view →
LUAD	All	All	+0.389	<.001	2	view →
CHOL	All	All	+0.422	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ZC3H12D–KIRC

Open the KIRC breakdown →