ZC3H12D

Across TCGA pan-cancer cohorts, ZC3H12D RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ZC3H12D data layer compared with 5 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZC3H12D RNA is associated with better overall survival. In most high-consensus cancer types, elevated ZC3H12D expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and LUAD are the cancer types where ZC3H12D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.452	0.270	<.001	152	view →
SKCM	OS	Median	All	0.420	0.266	<.001	142	view →
LUAD	OS	Median	All	0.778	0.598	<.001	101	view →
READ	OS	Tertile	II,III,IV	0.908	0.383	<.001	86	view →
CESC	OS	Tertile	All	0.850	0.683	.001	52	view →
UVM	DFS	Quartile	II,III,IV	0.438	0.916	.007	38	view →
THYM	DFS	Quartile	All	0.739	0.974	.003	36	view →
LGG	DFS	Median	All	0.668	0.802	<.001	36	view →
PAAD	OS	Median	II,III,IV	0.680	0.439	.001	27	view →
SARC	OS	Quartile	All	0.852	0.677	.007	22	view →
DLBC	DFS	Median	All	0.629	1.000	.017	21	view →
STAD	OS	Median	All	0.730	0.641	.017	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ZC3H12D–HNSC (OS)

Open the HNSC breakdown →