YWHAE

Across TCGA patient cohorts, YWHAE mutation is significantly associated with the RNA expression of many other genes, with 983 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YWHAE-associated genes across cancer lineages are RNU105C, LINC02876, and LINC00459. Each is linked with YWHAE in more than 2 cancer types. Because this analysis shows association rather than direction, both YWHAE-to-partner and partner-to-YWHAE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU105C grouped by YWHAE-low versus YWHAE-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YWHAE→partner) and Y-score (partner→YWHAE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU105C →	+0.427	+7.741	<.001	.009	3	3
CESC	LINC02876 →	+0.056	+5.010	.002	.009	3	2
UCEC	LINC00459 →	+0.188	+3.081	<.001	<.001	3	2
UCEC	ETF1P3 →	+0.114	+2.246	.004	<.001	3	2
UCEC	RN7SL248P →	+0.059	+3.137	<.001	.005	3	2
UCEC	ELMO2P1 →	+0.097	+1.709	.008	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 983 associations by consensus.

RNU105C by YWHAE expression — COAD

Explore this box plot interactively →