YWHAE

Across TCGA pan-cancer cohorts, YWHAE RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated YWHAE data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher YWHAE RNA is associated with worse overall survival. In most high-consensus cancer types, elevated YWHAE expression acts as an unfavorable survival marker, although some lineages such as UCEC and KIRC show a favorable association.

UVM, UCEC, and LUAD are the cancer types where YWHAE RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	II,III,IV	0.740	0.954	.002	74	view →
UCEC	DFS	Median	All	0.757	0.499	.001	70	view →
LUAD	DFS	Median	III,IV	0.473	0.773	<.001	66	view →
ACC	DFS	Median	All	0.246	0.612	<.001	64	view →
HNSC	OS	Tertile	All	0.252	0.571	.007	43	view →
KIRC	OS	Tertile	All	0.731	0.507	<.001	40	view →
KICH	OS	Median	All	0.749	0.970	.007	28	view →
MESO	DFS	Median	IV	0.186	0.524	.004	28	view →
BRCA	DFS	Median	IV	0.750	0.356	.006	26	view →
LIHC	OS	Median	All	0.719	0.831	.001	25	view →
SARC	OS	Tertile	All	0.398	0.586	.003	17	view →
SCLC	OS	Median	IV	0.219	0.729	.003	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

YWHAE–UVM (OS)

Open the UVM breakdown →