YWHAE

Across TCGA pan-cancer cohorts, YWHAE RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of YWHAE’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where YWHAE RNA is more highly expressed in tumor relative to normal tissue. In most cancer types YWHAE is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

HNSC, BLCA, and STAD are the cancer types where YWHAE tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in YWHAE RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.662	<.001	12	view →
BLCA	All	III,IV	+0.732	<.001	9	view →
STAD	All	II,III,IV	+0.671	<.001	8	view →
COAD	All	II,III,IV	+0.380	.001	8	view →
KICH	Female	II,III,IV	−1.569	<.001	7	view →
LIHC	Female	II,III,IV	+0.730	<.001	6	view →
UCEC	All	All	+0.631	<.001	6	view →
CHOL	Male	All	+1.796	<.001	5	view →
LUSC	Male	All	+0.327	<.001	4	view →
ESCA	All	All	+0.780	.005	2	view →
KIRP	Female	II,III,IV	+0.684	.029	2	view →
PRAD	All	All	+0.280	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

YWHAE–HNSC

Open the HNSC breakdown →