XIAP

Across TCGA patient cohorts, XIAP mutation is significantly associated with the RNA expression of many other genes, with 5,366 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XIAP-associated genes across cancer lineages are SNORD127, RN7SL134P, and LINC00909. Each is linked with XIAP in more than 2 cancer types. Because this analysis shows association rather than direction, both XIAP-to-partner and partner-to-XIAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD127 grouped by XIAP-low versus XIAP-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XIAP→partner) and Y-score (partner→XIAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SNORD127 →	+1.086	+3.752	<.001	.002	3	3
UCEC	RN7SL134P →	+0.083	+1.911	.001	.001	3	2
UCEC	LINC00909 →	+0.294	+1.871	.007	.004	3	2
UCEC	RPARP-AS1 →	+0.386	+1.748	<.001	.002	3	2
UCEC	MPI →	+0.288	+1.522	.007	.009	3	2
UCEC	MRFAP1 →	+0.476	+4.212	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,366 associations by consensus.

SNORD127 by XIAP expression — COAD

Explore this box plot interactively →