Q-omics provides the consensus-scored SNORD127 profile across patient tissues and cancer cell-line models. SNORD127 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, SNORD127 is differentially expressed in 5, with the highest sampling consensus in COAD. Additionally, SNORD127 RNA expression shows 11,240 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight HNSC, COAD, and THYM as cancer lineages where SNORD127 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SNORD127 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SNORD127 survival associations across molecular data types. SNORD127 RNA expression shows survival associations in the most cancer types (23). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SNORD127 RNA expression–survival associations across cancer types. High SNORD127 expression shows unfavorable associations in HNSC, UCEC, DLBC and GBM, but favorable associations in BRCA and STAD. The HNSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for SNORD127 RNA expression.
This table summarizes SNORD127 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in KIRP for RNA.
This table ranks reproducible tumor–normal expression differences for SNORD127. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SNORD127 shows higher tumor expression in COAD, KIRP, PAAD, CHOL and LUAD. The COAD box plot shows higher SNORD127 RNA expression in tumor versus normal tissue (log2 FC = +0.560, t-test p = .017).
This table shows molecular features associated with SNORD127 in patient tissues and cancer cell lines. In patient samples, SNORD127 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
