SNORD127

Across TCGA pan-cancer cohorts, SNORD127 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SNORD127 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SNORD127 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNORD127 expression acts as an unfavorable survival marker, although some lineages such as BRCA and STAD show a favorable association.

HNSC, UCEC, and DLBC are the cancer types where SNORD127 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.497	0.640	<.001	100	view →
UCEC	DFS	Tertile	All	0.499	0.684	.005	60	view →
DLBC	DFS	Median	All	0.285	0.792	.002	50	view →
BRCA	OS	Tertile	All	0.980	0.950	.003	48	view →
GBM	OS	Median	All	0.198	0.308	.002	33	view →
STAD	OS	Median	All	0.484	0.351	.006	31	view →
LAML	DFS	Median	All	0.706	0.410	.001	30	view →
OV	OS	Tertile	III,IV	0.767	0.868	.001	30	view →
KICH	DFS	Quartile	III,IV	0.367	0.790	.028	29	view →
READ	DFS	Tertile	IV	0.327	0.696	.011	27	view →
BLCA	DFS	Quartile	III,IV	0.335	0.471	.017	25	view →
LUSC	OS	Tertile	IV	0.001	0.651	.025	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SNORD127–HNSC (DFS)

Open the HNSC breakdown →