XIAP

Across TCGA pan-cancer cohorts, XIAP RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of XIAP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where XIAP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types XIAP is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

HNSC, LIHC, and STAD are the cancer types where XIAP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in XIAP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.362	<.001	11	view →
LIHC	Male	All	+0.853	<.001	9	view →
STAD	All	II,III,IV	+0.915	<.001	8	view →
BLCA	Male	All	+0.604	.003	8	view →
LUAD	All	All	+0.401	<.001	6	view →
BRCA	All	II,III,IV	+0.326	<.001	6	view →
CHOL	All	All	+1.420	<.001	5	view →
KICH	All	All	−0.419	.009	3	view →
PRAD	All	All	+0.210	.016	2	view →
KIRP	Male	All	−0.317	.016	1	view →
THCA	All	All	−0.215	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

XIAP–HNSC

Open the HNSC breakdown →