WTAP

Across TCGA patient cohorts, WTAP mutation is significantly associated with the RNA expression of many other genes, with 1,760 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WTAP-associated genes across cancer lineages are RNU7-79P, LINGO1-AS2, and MIR3193. Each is linked with WTAP in more than 2 cancer types. Because this analysis shows association rather than direction, both WTAP-to-partner and partner-to-WTAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-79P grouped by WTAP-low versus WTAP-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WTAP→partner) and Y-score (partner→WTAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU7-79P →	+0.492	+3.894	<.001	.001	3	3
BLCA	LINGO1-AS2 →	+0.035	+4.122	<.001	.008	3	2
BLCA	MIR3193 →	+1.604	+3.938	<.001	.002	3	2
UCEC	RN7SL248P →	+0.048	+2.847	<.001	.008	3	2
UCEC	RNU6-806P →	+0.166	+2.943	<.001	.001	3	2
UCEC	IGHD3-9 →	+1.100	+2.120	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,760 associations by consensus.

RNU7-79P by WTAP expression — BLCA

Explore this box plot interactively →