WTAP

Across TCGA pan-cancer cohorts, WTAP RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of WTAP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where WTAP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types WTAP is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KICH, and LIHC are the cancer types where WTAP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WTAP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.765	<.001	11	view →
KICH	Female	II,III,IV	−1.815	<.001	10	view →
LIHC	Female	III,IV	+0.794	<.001	9	view →
THCA	Male	II,III,IV	−0.437	<.001	7	view →
STAD	All	II,III,IV	+0.563	<.001	6	view →
CHOL	Male	All	+1.763	<.001	5	view →
PAAD	All	All	−0.650	.010	4	view →
LUAD	Female	II,III,IV	−0.318	.020	4	view →
KIRC	All	All	+0.289	<.001	4	view →
BRCA	Female	All	−0.188	.001	4	view →
READ	Male	All	+0.576	.009	3	view →
ESCA	Female	All	+0.823	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

WTAP–HNSC

Open the HNSC breakdown →