WNT5B

Across TCGA patient cohorts, WNT5B mutation is significantly associated with the RNA expression of many other genes, with 863 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WNT5B-associated genes across cancer lineages are SMIM4, FANCA, and E2F4. Each is linked with WNT5B in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT5B-to-partner and partner-to-WNT5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM4 grouped by WNT5B-low versus WNT5B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT5B→partner) and Y-score (partner→WNT5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SMIM4 →	+0.732	+3.465	<.001	.003	3	2
SKCM	FANCA →	+0.650	+3.478	.001	.002	3	2
SKCM	E2F4 →	+0.496	+3.235	.002	.009	3	2
SKCM	B3GALNT2P1 →	+0.357	+2.846	<.001	.006	3	2
UCEC	LONP1 →	+0.629	+3.732	<.001	<.001	3	2
UCEC	RNU4-58P →	+0.276	+3.018	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 863 associations by consensus.

SMIM4 by WNT5B expression — SKCM

Explore this box plot interactively →