WNT5B

Across TCGA pan-cancer cohorts, WNT5B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of WNT5B’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where WNT5B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types WNT5B is over-expressed in tumor, although a few such as BLCA and UCEC show the opposite, repressed pattern.

LUAD, BLCA, and UCEC are the cancer types where WNT5B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WNT5B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	II,III,IV	+0.806	<.001	8	view →
BLCA	All	IV	−1.850	.008	6	view →
UCEC	All	All	−1.122	.001	6	view →
BRCA	Female	All	−0.782	<.001	6	view →
LUSC	Female	All	+1.532	<.001	5	view →
KIRP	All	II,III,IV	+1.493	.005	5	view →
COAD	Male	All	−0.818	.002	5	view →
KICH	Female	All	−1.290	<.001	4	view →
HNSC	All	All	−0.573	.021	4	view →
CHOL	Male	All	+1.974	.009	3	view →
THCA	All	All	+0.285	.011	3	view →
PRAD	All	All	−0.587	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

WNT5B–LUAD

Open the LUAD breakdown →