WNT5B

Across TCGA pan-cancer cohorts, WNT5B RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated WNT5B data layer compared with 8 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher WNT5B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated WNT5B expression acts as an unfavorable survival marker, although some lineages such as ACC and LIHC show a favorable association.

ACC, LIHC, and MESO are the cancer types where WNT5B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.750	0.422	<.001	57	view →
LIHC	DFS	Quartile	All	0.516	0.276	<.001	45	view →
MESO	OS	Quartile	All	0.378	0.718	.002	44	view →
LGG	OS	Median	All	0.871	0.749	<.001	43	view →
SARC	OS	Median	All	0.662	0.822	<.001	35	view →
THYM	DFS	Tertile	All	0.951	0.767	.004	27	view →
OV	OS	Quartile	III,IV	0.616	0.726	.016	24	view →
KIRC	DFS	Quartile	All	0.556	0.807	.005	22	view →
BLCA	OS	Median	All	0.563	0.652	.015	17	view →
LUAD	OS	Median	II,III,IV	0.661	0.502	.029	14	view →
UVM	OS	Median	III,IV	0.589	0.966	.011	13	view →
SKCM	DFS	Median	IV	0.763	0.187	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

WNT5B–ACC (DFS)

Open the ACC breakdown →