WIPI1

Across TCGA patient cohorts, WIPI1 mutation is significantly associated with the RNA expression of many other genes, with 1,477 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WIPI1-associated genes across cancer lineages are TUBB4BP1, RN7SKP43, and FTLP4. Each is linked with WIPI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WIPI1-to-partner and partner-to-WIPI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUBB4BP1 grouped by WIPI1-low versus WIPI1-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WIPI1→partner) and Y-score (partner→WIPI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TUBB4BP1 →	+0.365	+5.857	<.001	.002	3	2
GBM	RN7SKP43 →	+0.203	+5.352	<.001	.005	3	2
HNSC	FTLP4 →	+0.116	+5.241	<.001	.007	3	2
UCEC	MIR7702 →	+0.191	+3.973	<.001	.006	3	2
LUSC	RNA5SP509 →	+0.373	+7.924	<.001	.008	3	2
LUAD	MIR6879 →	+0.686	+7.930	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,477 associations by consensus.

TUBB4BP1 by WIPI1 expression — GBM

Explore this box plot interactively →