WIPI1

Across TCGA pan-cancer cohorts, WIPI1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of WIPI1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where WIPI1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types WIPI1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRP, BLCA, and LIHC are the cancer types where WIPI1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WIPI1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	All	+1.040	<.001	9	view →
BLCA	All	All	+0.670	.001	9	view →
LIHC	Female	II,III,IV	+1.199	<.001	8	view →
LUAD	All	II,III,IV	+0.467	<.001	8	view →
CHOL	All	All	+1.856	<.001	5	view →
THCA	Male	II,III,IV	−0.562	.001	5	view →
LUSC	All	All	+0.595	<.001	4	view →
KICH	All	All	−0.560	<.001	4	view →
BRCA	Female	All	+0.252	.001	4	view →
HNSC	Female	All	+0.517	.044	2	view →
KIRC	All	All	+0.182	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

WIPI1–KIRP

Open the KIRP breakdown →