WIPI1

Across TCGA pan-cancer cohorts, WIPI1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated WIPI1 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher WIPI1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated WIPI1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and COAD show a favorable association.

UVM, BLCA, and MESO are the cancer types where WIPI1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.381	0.800	<.001	132	view →
BLCA	DFS	Median	II,III,IV	0.450	0.564	.001	82	view →
MESO	OS	Median	All	0.415	0.660	<.001	75	view →
STAD	OS	Tertile	All	0.580	0.877	<.001	56	view →
LGG	DFS	Median	All	0.647	0.826	<.001	54	view →
KICH	OS	Median	All	0.685	1.000	.003	46	view →
LUAD	OS	Quartile	II,III,IV	0.665	0.280	<.001	46	view →
LIHC	DFS	Median	All	0.462	0.636	<.001	31	view →
COAD	OS	Tertile	IV	0.735	0.267	.001	30	view →
HNSC	DFS	Median	All	0.567	0.736	.005	30	view →
BRCA	OS	Quartile	II,III,IV	0.950	0.876	.008	28	view →
UCEC	DFS	Tertile	IV	0.681	0.321	.012	28	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

WIPI1–UVM (OS)

Open the UVM breakdown →