WFDC8

Across TCGA cell cohorts, WFDC8 RNA expression is significantly associated with the mutation status of many other genes, with 110 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible WFDC8-associated genes across cancer lineages are ARHGAP31, PKD2L1, and RGSL1. Each is linked with WFDC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both WFDC8-to-partner and partner-to-WFDC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARHGAP31 grouped by WFDC8-low versus WFDC8-high in URINARY_TRACT.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WFDC8→partner) and Y-score (partner→WFDC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ARHGAP31 →	+4.044	+0.052	.001	<.001	3	2
BLOOD_Lymphoma	PKD2L1 →	+4.867	+0.022	.009	<.001	3	2
BLOOD_Lymphoma	RGSL1 →	+4.867	+0.022	.009	<.001	3	2
BREAST	SPTA1 →	+3.963	+0.032	.003	<.001	3	2
LUNG_NSCLC_LUAD	SDK1 →	+2.434	+0.008	.005	<.001	3	2
LUNG_NSCLC_LUAD	GIGYF2 →	+3.604	+0.010	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 110 associations by consensus.

ARHGAP31 by WFDC8 expression — URINARY_TRACT

Explore this box plot interactively →