WFDC8

Across TCGA pan-cancer cohorts, WFDC8 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated WFDC8 data layer compared with 3 for mutation status.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher WFDC8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated WFDC8 expression acts as an unfavorable survival marker, although some lineages such as BLCA and BRCA show a favorable association.

LIHC, KIRC, and LUSC are the cancer types where WFDC8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Tertile	All	0.187	0.451	<.001	69	view →
KIRC	DFS	Quartile	III,IV	0.302	0.508	.001	66	view →
LUSC	OS	Tertile	All	0.303	0.423	.015	66	view →
BLCA	OS	Quartile	IV	0.703	0.400	.003	57	view →
DLBC	DFS	Tertile	III,IV	0.074	0.984	.003	40	view →
BRCA	OS	Quartile	III,IV	0.718	0.481	.011	23	view →
LGG	OS	Tertile	All	0.845	0.905	.009	21	view →
SCLC	DFS	Tertile	All	1.000	0.652	.018	17	view →
THCA	DFS	Median	III,IV	0.778	0.934	.008	13	view →
LAML	DFS	Tertile	All	0.504	0.319	.048	12	view →
READ	OS	Tertile	II,III,IV	0.874	0.565	.040	10	view →
OV	OS	Tertile	All	0.743	0.645	.016	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

WFDC8–LIHC (DFS)

Open the LIHC breakdown →