WFDC8

Across TCGA pan-cancer cohorts, WFDC8 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of WFDC8’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where WFDC8 RNA is repressed in tumor relative to normal tissue. In most cancer types WFDC8 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, BRCA, and UCEC are the cancer types where WFDC8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WFDC8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−0.355	<.001	7	view →
BRCA	Female	All	−0.084	<.001	6	view →
UCEC	All	All	+0.445	.002	4	view →
ESCA	All	II,III,IV	+0.110	.031	2	view →
LUAD	Female	II,III,IV	+0.037	.028	2	view →
KIRC	All	II,III,IV	−0.022	.016	2	view →
STAD	Male	All	+0.037	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

WFDC8–THCA

Open the THCA breakdown →