VIRMA

Across TCGA cell cohorts, VIRMA mutation is significantly associated with the RNA expression of many other genes, with 179 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VIRMA-associated genes across cancer lineages are OR2T35, OR1Q1, and C1orf185. Each is linked with VIRMA in more than 2 cancer types. Because this analysis shows association rather than direction, both VIRMA-to-partner and partner-to-VIRMA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T35 grouped by VIRMA-low versus VIRMA-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VIRMA→partner) and Y-score (partner→VIRMA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR2T35 →	+0.056	+3.523	.004	.009	3	2
LARGE_INTESTINE	OR1Q1 →	+0.113	+1.962	.007	.006	3	2
LUNG_NSCLC_LUAD	C1orf185 →	+0.035	+3.150	<.001	.006	3	2
URINARY_TRACT	OR1A1 →	+0.006	+5.087	<.001	.004	3	1
BLOOD_Leukemia	OR5B21 →	+0.051	+1.874	.002	.008	1	3
SOFT_TISSUE	DEFB131B →	+0.433	+5.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 179 associations by consensus.

OR2T35 by VIRMA expression — BLOOD_Lymphoma

Explore this box plot interactively →