VIRMA

Across TCGA pan-cancer cohorts, VIRMA RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of VIRMA’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where VIRMA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VIRMA is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where VIRMA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VIRMA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.213	<.001	12	view →
KIRC	All	All	+0.419	<.001	10	view →
LIHC	Male	II,III,IV	+1.462	<.001	9	view →
THCA	All	II,III,IV	−0.436	<.001	9	view →
LUAD	Male	All	+0.668	<.001	7	view →
COAD	Male	All	+0.463	<.001	7	view →
STAD	Male	II,III,IV	+0.978	<.001	6	view →
LUSC	Male	II,III,IV	+0.699	<.001	6	view →
BRCA	All	III,IV	+0.679	<.001	6	view →
CHOL	All	All	+1.681	<.001	5	view →
UCEC	All	All	−0.384	.021	2	view →
KICH	Female	All	−0.558	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

VIRMA–HNSC

Open the HNSC breakdown →