USP45

Across TCGA patient cohorts, USP45 mutation is significantly associated with the RNA expression of many other genes, with 4,015 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP45-associated genes across cancer lineages are BMS1P13, UQCRBP3, and OR11J5P. Each is linked with USP45 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP45-to-partner and partner-to-USP45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BMS1P13 grouped by USP45-low versus USP45-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP45→partner) and Y-score (partner→USP45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BMS1P13 →	+0.059	+3.859	<.001	.006	3	2
UCEC	UQCRBP3 →	+0.089	+2.022	<.001	.004	3	2
UCEC	OR11J5P →	+0.009	+3.620	<.001	.009	3	2
LUAD	MIR552 →	+0.286	+7.930	<.001	.008	3	2
BLCA	MAGEA7P →	+0.109	+4.178	.001	.009	3	2
BLCA	DNAJB5P1 →	+0.241	+4.605	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,015 associations by consensus.

BMS1P13 by USP45 expression — BRCA

Explore this box plot interactively →