USP45

Across TCGA pan-cancer cohorts, USP45 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of USP45’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where USP45 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types USP45 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KICH, and LIHC are the cancer types where USP45 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP45 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.532	<.001	12	view →
KICH	Female	All	−0.889	<.001	5	view →
LIHC	All	All	+0.247	<.001	5	view →
STAD	All	II,III,IV	+0.664	.002	4	view →
LUSC	Male	All	+0.349	<.001	4	view →
THCA	All	All	−0.211	.004	4	view →
CHOL	All	All	+1.031	<.001	3	view →
LUAD	All	All	+0.347	.001	3	view →
BLCA	All	All	+0.290	.043	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

USP45–HNSC

Open the HNSC breakdown →