USP44

Across TCGA patient cohorts, USP44 mutation is significantly associated with the RNA expression of many other genes, with 1,756 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP44-associated genes across cancer lineages are DUSP15, TYMSOS, and ZWINT. Each is linked with USP44 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP44-to-partner and partner-to-USP44 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DUSP15 grouped by USP44-low versus USP44-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP44→partner) and Y-score (partner→USP44) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	DUSP15 →	-1.068	-3.453	.002	.005	3	3
UCEC	TYMSOS →	+0.750	+2.354	<.001	<.001	3	3
UCEC	ZWINT →	+0.679	+2.496	.001	.001	3	3
UCEC	DAD1 →	+0.392	+1.968	.003	.002	3	3
UCEC	ANKRD37 →	+0.593	+2.700	.002	.006	3	3
UCEC	WDHD1 →	+0.588	+1.931	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,756 associations by consensus.

DUSP15 by USP44 expression — SKCM

Explore this box plot interactively →